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Concomitantly, dysregulated GSH metabolism and impaired energy metabolism synergistically exacerbate hippocampal neuronal injury, forming a self-amplifying pathological loop (Figure 9)

After 3 years of continuous DFX treatment, 68.1% of patients with a baseline T2* ranging from 10 to 5 to 80% and disease-free survival of 74.5% in patients with -TM 39 years after undergoing allogeneic HSCT

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One small randomized controlled trial demonstrated that intravenous followed by oral thiamin therapy improved left ventricular ejection fraction in 30 CHF patients

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10.1080/10245332.2018.1456023 52 SharabiA.CohenE.SulkesJ.GartyM